The 26th Annual Trainee Research Symposium has been scheduled for Wednesday, March 3, 2010.
The deadline for submission of abstracts is Friday, January 29, 2010. To obtain abstract forms, download from http://www.dom.uab.edu/pdf/RFAandAbstractform.pdf.
All trainees of the Department of Medicine: Residents (i.e. housestaff PGY 1-3), Associate Fellows (i.e. subspecialty fellows – PGY 4-7), Post-doctoral Scholars (MD or PhD doing post-doctoral training in the Department of Medicine), and Graduate Students with Department of Medicine mentors (must be currently enrolled at UAB) are encouraged to submit one-page abstracts describing their original basic or clinical research. Each trainee may submit one abstract as first author. Abstracts submitted to other meetings for presentation this Spring or presented at recent meetings are eligible. Individuals holding a faculty appointment at the level of Instructor or above at the time of the Symposium are not eligible.
Contact: Paula Wood, 420 BDB 0012, 4-0700 E-mail: phwood@uab.edu
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Featured, News, Spotlight »
Martin E. Young, D.Phil.
Associate Professor
Division of Cardiology
ZRB 308
(205) 934-2328
meyoung@uab.edu
Circulation Res. Published online before print December 10, 2009, doi: 10.1161/CIRCRESAHA.109.209346
Ischemia/Reperfusion Tolerance Is Time-of-Day-Dependent. Mediation by the Cardiomyocyte Circadian Clock
David J. Durgan ; Thomas Pulinilkunnil ; Carolina Villegas-Montoya ; Merissa E. Garvey ; Nikolaos G. Frangogiannis ; Lloyd H. Michael ; Chi-Wing Chow ; Jason R. B. Dyck ; and Martin E. Young.
Abstract: Rationale: Cardiovascular physiology and pathophysiology vary dramatically over the course of the day. For example, myocardial infarction onset occurs with greater incidence during the early morning hours in humans. However, whether myocardial infarction tolerance exhibits a time-of-day dependence is unknown. Objective: To investigate whether time of day of an ischemic insult influences clinically relevant outcomes in mice. Methods and Results: Wild-type mice were subjected to ischemia/reperfusion (I/R) (45 minutes of ischemia followed by 1 day or 1 month of reperfusion) at distinct times of the day, using the closed-chest left anterior descending coronary artery occlusion model. Following 1 day of reperfusion, hearts subjected to ischemia at the sleep-to-wake transition (zeitgeber time [ZT]12) resulted in 3.5-fold increases in infarct size compared to hearts subjected to ischemia at the wake-to-sleep transition (ZT0). Following 1 month of reperfusion, prior ischemic event at ZT12 versus ZT0 resulted in significantly greater infarct volume, fibrosis, and adverse remodeling, as well as greater depression of contractile function. Genetic ablation of the cardiomyocyte circadian clock (termed cardiomyocyte-specific circadian clock mutant [CCM] mice) attenuated/abolished time-of-day variations in I/R outcomes observed in wild-type hearts. Investigation of Akt and glycogen synthase kinase-3beta in wild-type and CCM hearts identified these kinases as potential mechanistic ties between the cardiomyocyte circadian clock and I/R tolerance. Conclusions: We expose a profound time-of-day dependence for I/R tolerance, which is mediated by the cardiomyocyte circadian clock. Further understanding of I/R tolerance rhythms will potentially provide novel insight regarding the etiology and treatment of ischemia-induced cardiac dysfunction.
Awards & Funding, Featured, News »
The Department of Pathology is pleased to announce the availability of 3 fellowship positions for Ph.D./MSTP students training in the general area of cardiovascular pathophysiology. These awards are funded by a recently renewed five-year NIH pre-doctoral training grant (T32), which is now in year 12. These Fellowships are available for 12 months as follows: 02/01/10 – 01/31/11. Read more »
Events, Featured, News »
The Clinical Research Seminar is a monthly, one hour seminar where junior and senior faculty at UAB present their clinical research findings to the residents, fellows, and faculty of the Department of Medicine.
“Surveillance of Illness in International Travelers: The GeoSentinel Experience”
Speaker: David Freedman, MD, Professor of Medicine and Epidemiology
Director, UAB Travelers Health Clinic
Division of Infectious Diseases
UAB Department of Medicine
Monday, January 25, 2010, 12:00 Noon
West Pavilion Conference Room E
Sponsored by Chairman’s Office, Department of Medicine
Contact: Paula Wood 4-0700
Awards & Funding, Deadlines, Featured, News »
The Department of Medicine announces the availability of the Walter B. Frommeyer, Jr., Fellowship in Investigative Medicine designed to foster the development of outstanding physician-scientists by supporting a two-year intensive, mentored research experience. The candidate must have a clinical doctoral degree, e.g. M.D. or D.O. and be enrolled in clinical training programs in the Department of Medicine at UAB.
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2010 TRS, Events, Featured, News »
Department of Medicine Medical Grand Rounds
“The Joys of Translational Research”
Barry S. Coller, MD
David Rockefeller Professor of Medicine; VP for Medical Affairs;
Physician-in-Chief, Allen and Frances Adler Laboratory of Blood and Vascular Biology
The Rockefeller University, New York, New York
Time: March 3, 2010 at 12:00 Noon
Place: Margaret Cameron Spain Auditorium (box lunches served)
Poster Session
Time: March 3, 2010 from 1:00 – 3:00 PM
Place: North Pavilion Atrium
About
Active Grants for the Department of Medicine, reported by the UAB Office of Grants and Contracts Administration as of 3/01/2009, totaled $113 million.
